Recombinant Carboxypeptidase B, GMP Grade
CAS No. 9025-24-5
GMP-grade C-Terminal Cleavage Enzyme for Biologics Manufacturing
Ordering Information
| Size / Format | Cat. No. | Description | Action |
|---|---|---|---|
| 1 g | PB-05-001g | Recombinant CPB, GMP Grade, 1 g | Order |
Overview
GMP Grade rCPB is the regulatory-compliant manufacturing counterpart to Sequencing Grade CPB, produced under GMP conditions with full documentation support. It is used as a downstream processing reagent in mAb manufacturing to enzymatically control C-terminal Lys/Arg heterogeneity as a CQA management strategy. Full traceability and defined specific activity support process validation across development and commercial manufacturing.
Key Benefits
GMP-grade manufacture with full documentation support including Certificate of Analysis and Certificate of Origin
Specifically cleaves C-terminal Lys and Arg residues for controlled removal of basic C-terminal heterogeneity
Recombinant and animal-component free and is suitable for GMP-compliant downstream processing
Defined specific activity and purity specifications for process validation support
Available in 1 g format for manufacturing-scale applications
Compatible with standard biopharmaceutical processing buffers
Supports ICH Q6B CQA management strategies for therapeutic monoclonal antibodies
Product Specifications
| Grade | GMP Grade |
| Enzyme Source | Recombinant; animal-component free |
| Specificity | Cleaves C-terminal Lys and Arg residues |
| Form | Frozen Liquid |
| Storage Condition | −15°C to −25°C |
| Optimal pH | 7.5–9.0 |
| Cofactor | Zn²⁺ (metalloenzyme; avoid metal chelators such as EDTA) |
| Purity | >95% by SDS-PAGE; CoA provided per lot |
| Documentation | CoA, Certificate of Origin, GMP compliance documentation available |
