Pegaspargase is a PEGylated form of L-Asparaginase, where in Asparaginase is glycol conjugated with mono-methoxy polyethylene glycol (M-PEG). The conjugated enzyme exhibits higher catalytic activity, stability with low hypersensitivity. The molecular weight of Pegaspargase is in the range of 450 to 550 kDa with 90 to 100% PEGylation.
Pegaspargase is GMP manufactured in a certified facility with animal component free certified raw materials.
Pegaspargase improves the circulation time in blood and shows resistance to proteolytic reactions. It is used in the treatment of acute lymphocytic leukaemia (ALL), Non-Hodgkin’s lymphoma and when hypersensitive to another form of Asparaginase.